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Finally, the study examines in some depth the new

The synthesis of the intermediates (type I and II) from the corresponding carboxylic acid is a two step process. The oxidative addition of methacrylic/crotonic acids to nickel(0) only occurs in the presence of one molar equivalence of tricyclohexylphosphine, a highly electron donating sterically demanding phosphine. The second reaction to form complexes of die type [L(_2)Ni] (I) and [L(_2)Ni] (II) is a ligand displacement reaction.

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They are also associated with functional foods and processes by which environmental pollutants damage health. However, methods for screening compounds for their potential RXR targeting ligand activity have so far proved slow and awkward. Associate Professor KAKUTA Hiroki at University of Okayama Graduate School of Medicine and Shogo Nakano at the University of Shizuoka in Japan, and their colleagues have now demonstrated an assay based on a synthetic compound CU 6PMN referred to as 10 that can screen for RXR targeting ligand activity in hours instead of days with no complex equipment or radioactive isotopes needed..

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